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Dementia 2016
September 29-October 01, 2016
Volume 6 Issue 5(Suppl) J Alzheimers Dis Parkinsonism 2016
ISSN:2161-0460 JADP, an open access journal
conferenceseries .com
September 29-October 01, 2016 London, UK
5th International Conference on
Alzheimer’s Disease & Dementia
Heejin Park, J Alzheimers Dis Parkinsonism 2016, 6:5(Suppl)
Inhibition of mitochondrial fission ameliorates the pathogenesis of Alzheimer’s disease
Heejin Park
Sungkyunkwan University, Republic of Korea
Excessive mitochondrial fission is a prominent early event, and contributes to mitochondrial dysfunction, synaptic failure
and neuronal cell death in the progression of Alzheimer’s disease (AD). In the present study, we examine the role of
Drp1, a key regulator of mitochondrial fragmentation, in mitochondrial and synaptic dysfunction-induced by Aβ, and AD-
like neuropathology and cognitive functions in AD mice. Our results demonstrate that the inhibition of Drp1 alleviates
mitochondrial fragmentation, loss of mitochondrial membrane potential, ROS production, and ATP reduction in neurons
treatedwithAβ oligomers. An inhibitor of Drp1 also significantly restoresAβ-mediateddepressionof synaptic vesicle exocytosis.
Furthermore, Drp1 inhibition significantly improves learning and memory, synaptic density, and prevents mitochondrial
fission, lipid peroxidation, BACE1 expression and Aβ deposition in an AD mouse model. These results provide evidence that
Drp1 plays an important role in Aβ-mediated and AD-related neuropathology, and in cognitive function in an AD animal
model. Thus, inhibiting excessive Drp1-mediated mitochondrial fission may be an efficient therapeutic avenue for AD.
Biography
Heejin Park is studying at Molecular Cell Biology laboratory, from Sungkyunkwan University School of Pharmacy, South Korea, for her M.S. Course. She completed
her bachelor degree from the Department of Genetic engineering of Sungkyunkwan University and decided to transfer to School of Pharmacy because she was
interested in neurodegenerative diseases and Alzheimer’s Disease. Now she is investigaing for the relationship between mitochondrial dysfunction and Alzheimer's
Disease.