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Journal of Clinical & Experimental Pharmacology | ISSN: 2161-1459 | Volume: 8
International Conference on
July 18-19, 2018 | Atlanta, USA
Pharmacology and Ethnopharmacology
11
th
International Conference and Exhibition on
Pharmaceutical Oncology
&
Comparing anticonvulsant effects of viola extract and carbamazepine on mice model of PTZ-induced
seizure
Mehrdad Modaresi
Islamic Azad University, Iran
T
he seizure is a set of central nervous system disorders which appears as sudden, fleeting, recurrent and unpredictable convulsions
with sensorimotor and autonomic origin. Various chemical drugs are used to treat seizure and its following convulsions. These
drugs have side effects and also a long-term use of them causes medicinal resistance. Viola has been used in traditional medicine to
cure convulsion. Ease of use of medicinal plants and their popularity has provided fertile ground for the use of them. In view of the
prevalence of seizure and side effects of chemical drugs such as carbamazepine, this study was carried out to compare anticonvulsant
effects of viola and carbamazepine on an animal model of seizure. Forty laboratory mice were being chosen and further divided
into five groups: control, carbamazepine, and viola extract in 50, 100, and 200 mg/kg doses and these laboratory mice were being
injected intraperitoneal one hour before pentylenetetrazole injection. Studied factors were: lack of animal’s responding, duration of
tonic, clonic and generalized convulsions and percentage of mortality. According to results, viola in 50 mg/kg dose was different from
control group only in tonic-clonic stage and total convulsion time but 100 and 200 mg/kg groups showed significant differences from
the control group in all stages (p<0.05). Mortality of 200 mg/kg group was also less than other groups which show a protective effect
of viola extract. On the whole, hydroalcoholic extract of viola flower in 200 mg/kg dose can be proposed as an effective medication
for preventing convulsion of an animal model.
mehrdad_modaresi@hotmail.comClin Exp Pharmacol 2018, Volume: 8
DOI: 10.4172/2161-1459-C1-029