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Page 69
Journal of Clinical & Experimental Pharmacology | ISSN: 2161-1459 | Volume: 8
International Conference on
July 18-19, 2018 | Atlanta, USA
Pharmacology and Ethnopharmacology
11
th
International Conference and Exhibition on
Pharmaceutical Oncology
&
Safetyassessment:
In-vivo
anti-trpanosomalactivityofmethanol rootextractof
Securidacalongepedunculata
in mice infected with Trypanosoma brucei
Y Haruna
Kebbi State University of Science and Technology, Nigeria
S
ecuridaca longepedunculata
: A savannah shrub mainly found in Nigeria and used by traditional medicine practitioners. This
savannah shrub shows more than one hundred medicinal indications. The study aims at assessing the safety of the plant which
is 2.8 mg/kg, and its trypanocidal activity using Swiss albino mice of both sexes: The animals were randomly selected and divided
weight dependently into groups of 5 mice each, consisting of three methanol extracts groups of 5%, 10%, and 20% of the extract’s
LD50 which is equivalent to (0.14, 0.28, and 0.56mg/kg) respectively, and also a standard control drug (diminazene aceturate 3.5mg/
kg), infected and not treated group and no infection no treatment group. Except the no infection no treatment group, all other
groups were infected with
T. brucei
. Invariably, each animal received inoculums of about 1.0 x 107 parasites per gram body weight
through needle passage and produced parasitemia in the mice. On commencement of the medications, the methanol root extract
of
S. longepedunculata
was given to the three groups in divided doses for seven days and the diminazene aceturate was given at a
therapeutic dose of 3.5 mg/kg just once. All the drugs were given through intra-peritoneal routes after confirming parasitemia.
harufna@yahoo.comClin Exp Pharmacol 2018, Volume: 8
DOI: 10.4172/2161-1459-C1-029