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conferenceseries
.com
Volume 8
Journal of Gastrointestinal & Digestive System
Gastro Meet 2018
August 06-07, 2018
August 06-07, 2018 Abu Dhabi, UAE
Gastroenterology and Digestive
Disorders
16
th
International Conference on
J Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C3-071
Doxycycline related hepatotoxicity
Saba Vahdat
Islamic Azad University of Medical Sciences, Iran
Background and objective:
While Tetracyclines are known to cause liver damage, few drug surveillance studies have examined
the risk of hepatotoxicity developed by Doxycycline. Doxycycline is commonly used for vaginitis, bronchitis and acne. Therefore
the objective of this study is to determine the risk of hepatotoxicity in patients receiving Doxycycline.
Participants and Methods:
This matched case-control study is using Imam Reza clinic data. The cases were defined as recipients
who had at least one diagnosis of hepatotoxicity during a 1.5 year period (from 23 October 2015 till 23May 2017). The population:
96 cases plus 154 controls in the study. Covariates controlled for in the analysis were age, gender, use of other medications, alcohol
or drug use.
Main outcome measures:
doxycycline exposure prevalence and hepatotoxicity.
Results:
current or past users of Doxycycline did not have an increased risk of hepatotoxicity. Current use: (OR 1.39, 94%, CI
0.63- 3.74). Past use: (OR 1.71, 94%, CI 0.22- 3.11).
Conclusions:
The findings of the study suggested no increased risk of hepatotoxicity risk associated with Doxycycline exposure in
the study population. Doxycycline could potentially be a safe substitute for tetracycline, when appropriate.
sabavf.68@gmail.com