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conferenceseries
.com
Volume 8
Journal of Gastrointestinal & Digestive System
Gastro Meet 2018
August 06-07, 2018
August 06-07, 2018 Abu Dhabi, UAE
Gastroenterology and Digestive
Disorders
16
th
International Conference on
Rate of
Helicobacter pylori
eradication by levofloxacin based and clarithromycin based sequential
therapy regimens at tertiary care hospital
Ghulam Mujtaba Dahri
Liaquat National Hospital, Pakistan
Introduction:
Helicobacter pylori
infection has been recognized as one of the most common chronic bacterial infections in
humans. Many
H. pylori
eradication regimens have been described. There are little data reporting their efficacy or integration in
routine clinical practice.
Objective:
The aim of the current study is to find the rate of
H. pylori
eradication by levofloxacin based and clarithromycin based
sequential therapy regimens at tertiary care hospital.
Study design:
Study was conducted on out patients at Department of Gastroenterology, Liaquat National Hospital, Karachi.
Duration of study:
Six months from 23
th
Oct 2016 to 23
th
Apr 2017.
Subject & Methods:
All in patients who fulfilled the inclusion criteria in the Department of Gastroenterology, Liaquat National
Hospital, Karachi were included in the study. After taking informed written consent history, clinical examination, upper GI
endoscopy was performed levofolxacin and clarithromycin based sequential
H. pylori
eradication was given. Eradication was
checked by performing stool for
H. pylori
eradication. All the collected information was entered in the prescribed Performa.
Results:
A total 254 patients were included in our study. 106 (41.7%) were female and 148 (58.2%) were male. Mean duration of
dyspepsia was 5.03±1.24 months. Eradication rate was 95% with levofloxacin based sequential therapy and 85% with clarithromycin
based regime.
Conclusion:
The eradication rate with levofloxacin sequential therapy was better than clarithromycin based regime, could be due
to high resistance in our population so it is suggested to prefer levofloxacin based regime in our day to day practice.
Dr_gm18@yahoo.comJ Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C3-071