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Volume 8
Journal of Gastrointestinal & Digestive System
Gastroenterology Congress 2018
August 06-07, 2018
August 06-07, 2018 Osaka, Japan
14
th
Annual Congress on
Gastroenterology & Hepatology
J Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C4-074
Aldose reductase inhibitors of plant origin in the treatment and prevention of fatty liver disease
Longxin Qiu
Longyan University, China
F
atty Liver Disease (FLD) is a growing public health problem worldwide. The requirement for alternative and natural
medicine has been increasing rapidly and considerably. Recently, Aldose Reductase (AR)/polyol pathway has been reported
to be involved in the development of FLD, therefore it is of interest to study the effect of plant-derived AR inhibitors on FLD.
By conducting some investigations and by reading through literatures regarding AR inhibitors and FLD, we propose that
plant-derived AR inhibitors may block AR/polyol pathway and in turn reduce the fructose production and the subsequent
fat accumulation in liver in diabetic or high glucose diet-fed mice. Moreover, we propose that in rodents with alcoholic liver
disease or non-alcoholic fatty liver disease/nonalcoholic steatohepatitis, AR inhibitors may improve PPARα-mediated fatty acid
oxidation and reduce hepatic steatosis, and may attenuate CYP2E1-mediated oxidative stress or AR/gut bacterial endotoxin-
mediated cytokines overproduction to alleviate progression of FLD. We conclude that potent AR inhibitors of plant origin may
be efficient drugs for the treatment and prevention of FLD.
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