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.com
Volume 7, Issue 4 (Suppl)
J Clin Trial
ISSN: 2167-0870 JCTR, an open access journal
Global Pharmacovigilance 2017
July 06-07, 2017
JULY 06-07, 2017 KUALA LUMPUR, MALAYSIA
8
TH
GLOBAL
Pharmacovigilance &
Drug Safety Summit
Method of calculation the actual values of the parameters of drug elimination
Ilin A I and Asmanova N
Scientific Center for Anti-Infection Drugs, Kazakhstan
S
tatement of the Problem: The half-life t
1/2
or t
1/2(β)
is an indispensable characteristic to any drug, because it is one of the
pharmacokinetic (PK) parameters required for the calculation of its dosage regimen. But, now in use the methods of
calculation t
1/2
, which are valid only for the so-called monoexponential curve. They are also subject to the rule
t
1/2
/ MRT=ln 2, where MRT - mean residence time. In reality, there are many cases of deviation from it: ln 2 t
1.2
/MRT>1.
According to the results of our investigation [1], they are logically related with the number of compartments in a PK
parameters on base of curve C
10
(t) / C
0
=f (t) :a -model and mode of the drug administration, thus the relation (C
10
/ C
0
)
fix
→t
calc
, b - t
fix
→(C10 / C0 )
calc
t
1/ 2(β)
/ MRT can be recommended as an additional its characteristic. The aim of this study is
to devise a method for determining an actual values t
1/2
and MRT. Methodology & Theoretical Orientation: By analysis
of mathematical tool, numerical simulation and experimental data from literature it was shown, that to the determination of
the actual values t
1/2
and MRT instead PK curve of blood one must use the curve of the drug elimination from it. The problem
of non-uniqueness of solutions [2-5] can be avoided by using the value C
10
(t) / C
0
or its equivalent - AUC
0-t
/ AUC
0-α
. Findings:
Based on elimination curves it is possible to calculate not only an actual values t
1/2
and MRT, but also others parameters of
drug elimination: the time- t
calc
, required for the elimination from the blood of a given fraction of administered dose of drug
- (C
10
/ C
0
)
fix
, or, conversely, to find its value- (C
10
/ C
0
)
calc
at any point in time - t
fix
.
Conclusion & Significance: The proposed method make possible properly evaluate the parameters of drug elimination,
optimize the dosage regimen and, consequently, will enhance their effectiveness.
Biography
Ilin Aleksander I. - His research is associated with the development and creation of new drugs based on iodine-organic compounds. The main advantages of these
drugs are a wide spectrum of action and a practical lack of resistance to them in microorganisms.
The purpose of research, conducted by Asmanova Nazira in the last years - theory and practice of handling experimental data of pharmacokinetic studies of drugs.
This is due to the fact that some properties PK models and methods of estimation the values of PK parameters are still controversial or even incorrect, which can
lead to undesirable consequences.
ilin_ai@male.ru asmanova@inbox.ruIlin A I et al., J Clin Trial 2017, 7:4 (Suppl)
DOI: 10.4172/2167-0870-C1-017