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Volume 7, Issue 4 (Suppl)
J Clin Trial
ISSN: 2167-0870 JCTR, an open access journal
Global Pharmacovigilance 2017
July 06-07, 2017
JULY 06-07, 2017 KUALA LUMPUR, MALAYSIA
8
TH
GLOBAL
Pharmacovigilance &
Drug Safety Summit
J Clin Trial 2017, 7:4 (Suppl)
DOI: 10.4172/2167-0870-C1-017
Design, graph theoretical analysis,
in silico
modeling and synthesis of biologically active pyrimidines
as antimicrobial and antitubercular agent
Theivendren Panneerselvam
1
and Jithendar Reddy Mandhadi
2
1
Kalasalingam University, India
2
Satavahana University, India
A
series of 1-(2-(6-(4- substituted benzyl)-2-amino-5-carbamoylpyrimidin-4-yloxy) acetyl) thiosemicarbazide (S 1-25) 1-(2-
(6-(4- substituted benzyl)-2-amino-5-carbamoyl pyrimidin-4-yloxy)acetyl) semicarbazide (R 1-25) were developed using
different aromatic aldehydes, urea and thiourea. The synthesized compounds were characterized by IR, 1H-NMR and mass
spectrometry and these constitute attractive targets for the development of active antimicrobial as well as antimycobacterial
agent. Among the compounds tested both electron withdrawing and releasing compounds exhibited significant antibacterial
and antifungal activities while unsubstituted compounds also showed notable antifungal activity with reference to standard
drugs Clotrimazole. The most active and selective compounds carry a fluorine atom in the phenyl ring at
para
-position. In
conclusion, the potency and selectivity of these compounds make them valid lead compounds for synthesizing new analogues.
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