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conferenceseries
.com
Volume 8
Medicinal Chemistry
ISSN: 2161-0444
Medicinal Chemistry 2018
June 14-15, 2018
June 14-15, 2018 | Barcelona, Spain
10
th
World Congress on
Medicinal Chemistry and Drug Design
Electrochemical behaviour of duloxetine HCl drug in formulation and spiked human serum at a
carbon paste electrode
Youssef I Moharram
Tanta University, Egypt
T
he electrochemical behavior of duloxetine HCl (DXT.HCl) drug was investigated. Two precise linear sweep and square
wave adsorptive anodic stripping voltammetry methods have been described for its trace quantitation in pharmaceutical
formulation and human serum. Amechanism of its oxidation was reported and illustrated. The method shows the development
of a sensor for selective and sensitive determination of DXT.HCl. DXT.HCl has been oxidized at a CPE via 2-electron due
to oxidation of its secondary amino group. The strong adsorption phenomenon of DXT.HCl can be used as an effective
preconcentration step prior to the actual voltammetric quantification of the analyte. Two precise linear sweep and square wave
adsorptive anodic stripping voltammetry methods have been described for its trace quantitation in pharmaceutical formulation
and human serum. The methods were simple, rapid, and in expensive and sophisticated apparatus or expensive solvents, in
comparison with other methods used previously for the study of DXT.HCl. So the proposed method can be used for the routine
analysis of DXT.HCl, either alone or in its pharmaceutical formulations. However, the proposed SW-AdASV method has a
better detection limit in spiked human serum (LOD=2.1×10
−8
mol L
−1
), therefore it is sensitive enough for assay of DXT.HCl
in human plasma of real samples and for pharmacokinetic studies. It can be also recommended for its quantification in quality
control and clinical laboratories.
Biography
Youssef I Moharram has completed his PhD at Tanta University in Egypt and Leeds University in UK (Channel System). He has published more than 25 papers.
yimoharram@hotmail.comYoussef I Moharram, Med chem (Los Angeles) 2018, Volume 8
DOI: 10.4172/2161-0444-C1-039