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Volume 8 Medicinal Chemistry
ISSN: 2161-0444 Medicinal Chemistry 2018
June 14-15, 2018
June 14-15, 2018 | Barcelona, Spain
10th World Congress on
Medicinal Chemistry and Drug Design
Multicomponent access to conjugate vaccines
Yanira Méndez Gómez
Leibniz Institute of Plant Biochemistry, Germany
Though the discovery of antibiotics in the 20th century discouraged the application of carbohydrate based vaccines, the
appearance of bacterial resistance and the cuasi prohibitive access to really new antibiotics have turned the interest toward
new carbohydrate based vaccines. This work describes the development of a new synthetic strategy towards antibacterial
glycoconjugate- and specially multivalent vaccines. The conjugation of functionalized capsular polysaccharides of Streptococcus
pneumoniae and Salmonella enterica serovar Typhi to carrier proteins such as diphtheria and tetanus toxoids was caried out
via the Ugi 4-component reaction, giving access to mono and multivalent unimolecular glycoconjugates by conjugating them
to immunogenic proteins. This gives rise to opportunities toward multivalent and self-adjuvanting vaccines, which will be
reported.
Biography
Yanira Méndez Gómez received her academic education from the University of Havana. Currently, she is a PhD student in the group of Prof B Westermann, IPB, Germany
and the group of Prof D G Rivera, CEPN, Cuba. She is dealing with the synthesis and bioconjugation of capsular polysaccharides to carrier proteins and adjuvants to obtain
conjugate vaccine candidates. Simultaneusly, she is working as Lecturer in Department of Organic Chemistry at University of Havana.
Yanira Méndez Gómez, Med chem (Los Angeles) 2018, Volume 8
DOI: 10.4172/2161-0444-C1-039