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Journal of Obesity & Weight Loss Therapy | Volume: 08
August 28-29, 2018 | Paris, France
Obesity, Diet and Nutrition
17
th
International Conference on
To investigate the influence of polymorphisms in
PRDM16
and
PDE4D
genes which are involved in
thermogenesis process on obesity and blood lipids profile in Saudi population
Aisha Alamrani
Tabuk University, Saudi Arabia
Aim:
The aim of this study was to investigate the influence of polymorphisms in
PRDM16
and
PDE4D
genes which are involved in
thermogenesis process on obesity and blood lipids profile in Saudi population.
Methods:
A case control format was used that involved 89 obese individual and 84 non-obese (control). The
PRDM16
(rs2651899)
and
PDE4D
(rs295978) polymorphisms were genotyped using KASP
TM
(Competitive Allele-Specific PCR) method.
Results:
Participants with the mutated genotypes, AA and AG, of
PRDM16
(rs2651899) polymorphism were significantly more likely
to be obese as compared to participants with wild type genotype (OR=21, 95% CI=5.4190 to 84.4231, P value<0.0001 and OR=44.6,
95% CI=11.5984 to 172.0157, P value<0.0001, respectively). This polymorphism found to be significantly affecting the participants
blood lipids profiles. In contrast,
PDE4D
(rs295978) polymorphism was not associated with risk of obesity and had no effects on
blood lipids profile.
Conclusions:
We found that the
PRDM16
polymorphism (rs2651899) is a risk factor for obesity and influence blood lipids profiles
significantly in Saudi population. While the
PDE4D
(rs295978) polymorphism didn’t show significant effect on risk of obesity or
blood lipids profiles.
aiashah_atiah@hotmail.comJ Obes Weight Loss Ther 2018, Volume: 08
DOI: 10.4172/2165-7904-C5-070