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Journal of Obesity & Weight Loss Therapy | Volume: 08
August 28-29, 2018 | Paris, France
Obesity, Diet and Nutrition
17
th
International Conference on
Can insulin-like growth factor-1 (IGF-1) predict menstrual recovery in adolescents with anorexia nervosa
(AN)?
Vasileios Karountzos
1
, Pandelis Tsimaris
1
, Artemis Tsitsika
2, 5
, Flora Bacopoulou
3
, George Panotopoulos
1
, Nikolaos Athanasopoulos
1
, Anastasia Vatopoulou
4
,
Aikaterini Giannouli
1
, Konstantinos Panoulis
1
and Efthimios K Deligeoroglou
1
1
Aretaieion Hospital, Greece
2
National and Kapodistrian University, Greece
3
Aghia Sophia Children’s Hospital, Greece
4
Aristotle University of Thessaloniki, Greece
5
P & A Kyriakou Children’s Hospital, Greece
Aim:
The aim of this study was to assess whether insulin-like growth factor-1 (IGF-1) can be a good predictor of menstrual recovery
in girls with anorexia nervosa (AN).
Material & Methods:
Prospective study of adolescents presented with anorexia nervosa (AN) and amenorrhea in our department.
Anthropometric parameters, luteinizing hormone (LH), estradiol and IGF-1 levels were evaluated at the beginning and at the time of
menstrual recovery, while all girls were being treated for nutritional recovery.
Results:
Thirty eight adolescents with mean age 17.23±0.89 years, mean body mass index 16.67±2.46 Kg/m2, mean waist-hip ratio
0.77±0.12, mean waist circumference 0.67±0.09 m, mean LH 0.18±0.03 (IU/L), mean estradiol levels 23.46±5.77 pg/ml and mean
IGF-1 levels 126.56±23.77 ng/ml, were included in our study. Mean years of menstrual recovery were 2.76±0.62. All hormonal profiles
improved after resumption of menses and nutritional recovery, with IGF-1 correlating the most (p<0.0001), showing mean levels of
327.78±56.12 ng/ml.
Conclusions:
IGF-1 plays a crucial role as a predictor of menstrual recovery, although there is a big list of other hormonal and
anthropometric factors that should not be omitted during the evaluation and management of girls with AN.
vasiliskar1985@yahoo.comJ Obes Weight Loss Ther 2018, Volume: 08
DOI: 10.4172/2165-7904-C5-070