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Journal of Obesity & Weight Loss Therapy | Volume: 08
August 28-29, 2018 | Paris, France
Obesity, Diet and Nutrition
17
th
International Conference on
J Obes Weight Loss Ther 2018, Volume: 08
DOI: 10.4172/2165-7904-C5-070
DNAprotective and antioxidant effects ofAstragalus methanolic extract in streptozotocin-induced diabetic
rats
Besma Abed
University of Monastir, Tunisia
T
he protective effect of Methanolic Astragalus Roots (MAR) extract (250 and 500 mg/kg b.w) against oxidative stress was evaluated
in Streptozotocin (STZ) induced diabetes rats. Administration of MAR extract induces a significant decrease in ROS production,
Malondialdehyde (MDA) level, and protein carbonyl (PC) contents, and protects against DNA damage showed in diabetic rats.
Decreased superoxide dismutase and catalase enzymes activities revealed in pancreas, liver, kidney and brain-STZ-induced diabetes
groups were significantly restored in MAR-treated groups compared to the untreated diabetic group. Moreover, MAR extract was
able to reduce nitric oxide (NO) levels and to enhance phagocytic activity of macrophages. Our study demonstrated that MAR extract
may be effective against development of diabetes complications through the improvement of the oxidative status, especially in the
pancreas and liver. This could be an important support for further investigations of this bioactive plant in the development of dietary
supplement and pharmaceutical products.
abedbesma@yahoo.fr