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conferenceseries
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June 26-27, 2017 San Diego, USA
13
th
International conference on
Pathology and Molecular Diagnosis
Volume 7, Issue 2 (Suppl)
J Clin Exp Pathol, an open access journal
ISSN:2161-0681
Pathology and Molecular Diagnosis 2017
June 26-27, 2017
J Clin Exp Pathol 2017, 7:2 (Suppl)
DOI: 10.4172/2161-0681-C1-035
Study of possible relation between maternal serum resistin and insulin resistance in patients with
pre-eclampsia
Alyaa Ahmed El-Sherbeny, Manal Mohsen, Eman Abdelmoniem Algohary, Safeya Hamdy Hassan, Emad Abd El-mohsen Abd El-hadi and Abdel Latif
Galal El-kholy
Ain Shams University, Egypt
Introduction:
In humans resistin antagonizes the effects of insulin on glucose metabolism in liver and skeletal muscle, interacts
with and reinforces inflammatory pathways and may promote endothelial cell activation. Increased resistin levels have been
associated with obesity, insulin resistance, metabolic syndrome, type 2 diabetes and increased cardiovascular risk
Objectives:
Our study aimed to investigate the utility of maternal serum resistin in women with pre-eclampsia compared to
normal pregnant women and its relation to insulin resistance.
Methods:
The study was conducted on ninety (90) females, divided into two groups: - Group І: Pre-eclampsia (n=60) and
Group ІІ: Healthy pregnant Control (n=30). All individuals were subjected to the following after an informed oral and written
consent: Full history taking, clinical examination with special emphasis on edema, blood pressure measurement and Maternal
body mass index (BMI); Index (weight (kg)/height² (m²)), determination of gestational age according to the date of the last
menstrual period and confirmed by first trimester ultrasound. Laboratory investigations including CBC, AST, ALT, BUN,
creatinine, HOMA-IR and serum resistin were performed.
Results:
Statistical comparison between pre-eclamptic patients (Group I), and the healthy control group (Group II) regarding
the different studied parameters revealed a highly statistically significant increase in the patients group than the control group
regarding SBP, DBP, BMI, CRE, AST, ALT, 50 g oral glucose challenge test (GCT), FBG, fasting insulin, HOMAIR and resistin.
On the contrary, there was a highly statistically significant decrease in the patients group than the control group regarding HB.
Conclusion:
In this study, it was found that elevated serum resistin levels could be associated with exaggerated insulin resistance
in patients with pre-eclampsia. Further studies are needed to clarify the role of resistin in the patho-physiology of preeclampsia
and insulin resistance.
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