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Volume 5 Journal of Pharmaceutical Care & Health Systems Pharma Middle East 2018
November 05-07, 2018
November 05-07, 2018 Abu Dhabi, UAE
18th Annual
Pharma Middle East Congress
The cytotoxicity effect of two saponins from Gymnocarpos decander species on Hela cells
Mohamed Bouheroum1, Houria Bechlem1, Teresa Mencherini2 and Nunziatina De Tommasi2
1Constantine 1 University, Algeria
2University of Salerno, Italy
Themodern pharmaceutical industry reliesmainly on the diversity of plant secondarymetabolites to find newmolecules with
novel biological properties, in this perspective our objectives are the inventory as well as the chemical and pharmacological
evaluation of Algerian species, in order to valorize and rationalize their traditional uses and to isolate compounds of potential
therapeutic interest. The n-butanol and ethyl acetate extracts of Gymnocarpos decander (Caryophyllaceae) were able to isolate
five new products including two saponins and three flavanol glycosides, with three known products. The extract obtained
undergoes chromatographic and spectroscopic investigations in order to isolate and establish the structures of the molecules
that compose them by using various spectroscopic experiments (UV, 1D NMR and 2D and SM). In addition, the cytotoxicity
tests of the new compounds (1-5) isolated from the Butanol phase of Gymnocarpos decander performed on the three cell lines
Jurkat T (leukemia), Hela (cancer of the cervix) and MCF7 (breast cancer), have shown that only the products one and two
(both saponins) have a cytotoxic effect vis-a-vis the three cell lines, in particular Hela cells. These results of anti-proliferative
activity are encouraging and stimulate further research projects on the species of this family.
Biography
Mohamed Bouheroum has his research studies in Phytochemistry on Algerian Medicinal Plants looking for bioactive molecules. He has completed his Master’s
degree from Manchester University and PhD from the Constantine 1 University, Algeria. He is currently working as a Professor and Chief of a Team performing
phytochemistry researches on Algerian medicinal plants in Varenbimol laboratory at Constantine 1 University, Algeria.
Mohamed Bouheroum et al., J Pharma Care Health Sys 2018, Volume 5
DOI: 10.4172/2376-0419-C4-035