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.com
Volume 5
Journal of Pharmaceutical Care & Health Systems
Pharma Middle East 2018
November 05-07, 2018
November 05-07, 2018 Abu Dhabi, UAE
18
th
Annual
Pharma Middle East Congress
Comparative disintegrant properties of Ethiopian potato (
Plectranthus edulis
) starch against Irish
potato starch and its optimization in paracetamol tablet formulations
Anteneh Assefa
1
, Anteneh Belete
2
and Tsige Gebre-Mariam
2
1
Wachemo University, Ethiopia
2
Addis Ababa University, Ethiopia
S
tarch is the most commonly used pharmaceutical disintegrant in tablet formulations. The aim of the present study was to
assess the disintegrant property of Ethiopian potato (
Plectranthus edulis
) starch in comparison to Irish potato starch and
its optimization in paracetamol tablets formulations-prepared by wet granulation method. Tablet properties such as crushing
strength, friability, disintegration time and dissolution rate of the tablets were studied for both comparison and optimization
studies. The results of comparative study showed that the properties of paracetamol tablets formulated with both starches as
disintegrants were affected by their concentration and the Compression Force (CF) and
P. edulis
starch exhibited a favorably
comparable disintegrant property with Irish potato starch in paracetamol tablet formulations. The study also showed that
the CF and disintegrant concentration had significantly affected the response variables (i.e. the crushing strength, friability
and disintegration time); hence, these factors were further optimized using central composite statistical design. The optimal
conditions were obtained at a CF of 14.40 KN and disintegrant concentration of 5.96%. Under these conditions, the crushing
strength, friability and disintegration time were 101.8 KN, 0.3% and 1.34 min, respectively. These values closely matched
with the predicted values of the responses at the aforementioned levels of the factors. Thus, the results of this study indicated
that Ethiopian potato (
P. edulis
) can be used as an alternative source of starch for its application as a disintegrant in the tablet
formulations.
Biography
Anteneh Assefa is currently working as a Lecturer of Pharmaceutics and Pharmacology at Wachemo University, Ethiopia. He is an expertise of pharmaceutical
dosage form design and drug supply chain management.
ante2011@gmail.comAnteneh Assefa et al., J Pharma Care Health Sys 2018, Volume 5
DOI: 10.4172/2376-0419-C4-035