Volume 7, Issue 6(Suppl)
J Chromatogr Sep Tech
ISSN: 2157-7064 JCGST, an open access journal
Page 73
Notes:
Separation Techniques 2016
September 26-28, 2016
conferenceseries
.com
Separation Techniques
September 26-28, 2016 Valencia, Spain
2
nd
International Conference and Expo on
Supercritical CO
2
in its multiple roles: Solvent for fractionation of complex mixtures and blowing
agent in polymer foaming
Martin Topiar
1,2
, Marie Sajfrtova
2
, Helena Sovova
2
1
Institute of Chemical Process Fundamentals of the CAS, v.v.i., 16502, Prague, Czech Republic
2
University of Chemistry and Technology Prague, 166 28, Prague, Czech Republic
C
arbon dioxide in its supercritical state (sc-CO
2
) can find application in formation of microcellular polystyrene foams (PSF)
with improved thermal properties in comparison with PSF on the market. A most important application of sc-CO
2
on
industrial scale is supercritical fluid extraction (SFE) from plants. Both processes have been studied in our laboratory. Although
the SFE is more selective than common extraction methods, CO
2
extracts still contain a mixture of chemical compounds. If
a high concentrated isolate is required, suitable fractionation methods have to be involved into the process. Supercritical
adsorption, a novel promising method combining SFE from plants with selective adsorption of extracted compounds, could be
a solution when high purity isolates free of any traces of organic solvents are required. We used this method for fractionation
of turmeric (
Curcuma longa
L.) isolate obtained by SFE. The major compounds analyzed by GC were turmerone (22.7 wt.%),
ar-turmerone (13.2 wt.%) and curlone (13.8 wt%). Turmerones belong to widely studied substances with potential use in
the treatment of neurodegenerative diseases. The efficiency of fractionation was studied in terms of adsorption conditions,
adsorbent type and sorbent-to-feed ratio. The concentration of turmerones in isolate increased from the initial 49.7 wt.% up
to 93.8 wt% with using a particular type of silica gel. Moreover, the concentration of β-sesquiphellandrene, a compound with
a potential anticancer activity, in volatile fraction obtained from supercritical adsorption process was almost 16 times higher
than in the initial sample. These are promising results for a more detailed subsequent research on this method.
Acknowledgement:
The financial support from the Grant Agency of the Czech Republic via grant 14-18938S is gratefully acknowledged.
Biography
Martin Topiar has completed his Master of Science in Synthesis and Production of Drugs from University of Chemistry and Technology Prague. Presently he is a
PhD student at Institute of Chemical Process Fundamentals of the CAS, v.v.i. focusing on the SFE from plants with particular interest in a study of several types of
fractionation techniques. He has published 3 papers in reputed journals and presented his work in many international conferences dealing with supercritical fluids.
topiar@icpf.cas.czMartin Topiar et al., J Chromatogr Sep Tech 2016, 7:6(Suppl)
http://dx.doi.org/10.4172/2157-7064.C1.019