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Volume 5, Issue 2 (Suppl)
J Tradi Med Clin Natur
ISSN: JTMCN, an open access journal
Page 88
Traditional Medicine 2016
September 14-16, 2016
conferenceseries
.com
September 14-16, 2016 Amsterdam, Netherlands
6
th
International Conference and Exhibition on
Traditional & Alternative Medicine
J Tradi Med Clin Natur 2016, 5:2 (Suppl)
http://dx.doi.org/10.4172/2167-1206.C1.003The synergistic effect of aged garlic extract and methotrexate in collagen-induced rheumatoid
arthritis in male Albino rats
Gehan Moustafa Badr
King Faisal University, Saudi Arabia
A
ged Garlic Extract (AGE) exhibit a significant anti inflammatory effect in numerous diseases. However, the anti inflammatory
effects of AGE in arthritic conditions not well documented and the Methotrexate (MTX) is an anchor drug used to treat
rheumatoid arthritis (RA), but responsiveness is variable in effectiveness and hepatotoxicity in healthy and collagen-induced arthritis
(CIA)-rats. Therefore, the present study used adult female rats divided into 8 groups of rats: Control healthy, CIA, CIA treated
with AGE and/or MTX, healthy treated with AGE and/or MTX. Arthritis induced by intradermally injection of collagen complete
Freund's adjuvant (CFA) emulsion (4 mg/kg)at the base of the tail in each rat. All treatments started once the peak symptoms of
arthritis appeared (20th day). AGE treatment (from day 21 to 50) 200 mg/kg/PO. CIA-rats injected by subcutaneous dose of 1.5 mg/
kg per 2 days of MTX from day 21 to 43. Efficacy of AGE alone or combined with the medicine was assessed based on the ability to
reduce paw oedema, histopathological changes, reduction of the liver enzyme activities and oxidative parameters, elevation of hepatic
antioxidant enzymes, arthritis-induced changes in body weight, C-reactive protein (CRP), Serum Tumour Necrosis Factor (TNF) α
and interleukin (IL)-17 levels. The study aimed to evaluate the anti-inflammatory effect in CIA-rats of AGE alone and its synergetic
activity in combination treatment with methotrexate and its protection against methotrexate induce toxicity.
Provenance variation for seedling parameters of Cassia fistula L. in agro-climatic zones of northern
Karnataka
Shivanna H
1
, Renuka Nayak
1
, Surendra P
2
, Krishna A
1
, Manjunath G O
1
, Dasar G V
1
and
Patil H Y
3
1
College of Forestry, Sirsi, India
2
Agricultural Research Station (Paddy), Sirsi, India
3
UAS, Dharwad, India
W
orldHealthOrganization estimated that 80 per cent of the population of developing countries depends on traditional medicines.
Among which India’s contribution is 15-20 % for 2000 drugs of plant origin. Demand for medicinal plants is increasing because
of having no side effects, easily available at affordable prices and sometimes the only source of health care available to the poor. Cassia
fistula L. is an important medicinal plant valued for ornamental purposes.The present study was undertaken to evaluate the growth
performance of provenances of Cassia fistula from five agro climatic zones of northern Karnataka viz., North-eastern transition
zone, North-eastern dry zone, Northern dry zone, Northern Transitional zone and Hilly zone. Significant differences among the
provenances were observed for various seedling parameters. Results revealed that the seedlings grown from the seeds collected from
Hilly zone and Northern Transitional zone showed better performance. The maximum Chlorophyll content was found in Hilly zone
(21.90 mg/ g fresh weight) followed by Northern Dry zone (20.50 mg/ g fresh weight). However the lowest Chlorophyll content
was found in the North Eastern Transition Zone i.e. 19.10 mg/ g fresh weight. At 180 days after germination average relative water
content (%) varied significantly. Significantly more relative water content was recorded in Hilly zone (90.0). The lowest relative water
content was observed in Northern Dry zone (82.6). Therefore, seeds from these two provenances can be used for future afforestation
programme.