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Volume 5, Issue 2 (Suppl)
J Tradi Med Clin Natur
ISSN: JTMCN, an open access journal
Page 82
Notes:
Traditional Medicine 2016
September 14-16, 2016
conferenceseries
.com
September 14-16, 2016 Amsterdam, Netherlands
6
th
International Conference and Exhibition on
Traditional & Alternative Medicine
Trinh Thi Thuy et al., J Tradi Med Clin Natur 2016, 5:2 (Suppl)
http://dx.doi.org/10.4172/2167-1206.C1.003Chemical constituents and their biological activities from
Artocarpus tonkinensis
, a traditional
medicinal plant
Trinh Thi Thuy
1
, Dao Duc Thien
1
, Nguyen Thanh Tam
1
, Pham Thi Ninh
1
, Nguyen Thi Hoang Anh
1
, Tran Van Sung
1
, Do Thi Thao
2
, Sabrina Adorisio
3
and
Domenico V. Delfino
6
1
Vietnam Academy of Science and Technology, Vietnam
2
Vietnam Academy of Science and Technology, Vietnam
3
S. Maria Terni Hospital
4
University of Perugia, Italy
A
rtocarpus tonkinensis
A. Chev. ex Gagnep., occurs in North Vietnam and China. The decoction of its leaves have been for long
time used in Vietnamese traditional medicine (VTM) for the treatment of arthritis and backache. Intraperitoneal injections of
A.
tonkinensis
extract decreased both arthritis incidence and severity and delayed disease onset in rats with collagen-induced arthritis
[1]
.
Due to its promising pharmacological properties, we focused on the phytochemical studies of
Artocarpus tonkinensis
(AT) leaves for
possible use in alternative medicine. Ttwo auronol glucosides hovetrichoside C (maesopsin 4-O-b-D-glucoside, TAT2, 1), alphitonin-
O-b
-D-glucoside (2) and flavonoids including artonkin-4’-
O-b
-D-glucopyranosid (3), kaempferol (4), astragalin (5), kaempferol
3-rutinoside (6), kaempferol 3-neohesperidoside (7) and afzelechin-(4a®8’’)-catechin-3-
O-b
-D-glucopyranoside (8) were isolation
and structural identificated from aqueous 70% ethanolic leaf extract. The main compounds TAT2 has shown potent anti-proliferative
and anti-inflammatory effects both
in vitro
and
in vivo
[1]
. Kaempferol, quercetin, and their glycosidic derivatives are considered
potent antioxidants, anti-inflammatory ubiquitously distributed in plants. The anti-inflammatory activity of AT may be attributed to
its total flavonoids 1-8. These results suggest that AT can inhibit the inflammatory response and may represent a potential therapeutic
candidate for the treatment of chronic inflammatory diseases.
Biography
Trinh Thi Thuy, Ph.D., completed her Chemical doctor degree at the Institute of Chemistry (ICH), Vietnam Academy of Science and Technology (VAST). Her Ph.D.
in Phytochemistry at the Institute of Plant Biochemistry in Halle/S, Germany. She is the head of Natural Products Research Laboratory at the ICH, VAST. She has
published more than 20 papers in peer-reviewed international journals.
thuy@ich.vast.vn