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Volume 6, Issue 2 (Suppl) Virol-mycol
ISSN: 2161-0517 VMID, an open access journal Virology Asia 2017
May 11-12, 2017
May 11-12, 2017 Singapore
10th World Congress on
Virology and Mycology
High prevalence of HPV in odontogenic cysts
Mohammad Amin Khajavi
Mashhad University of Medical Science, Iran
Introduction: Human papilloma virus is one of the DNA viruses which seems to be a causative factor in benign and malignant
epithelial proliferation by synthesis of special oncoproteins so that they are considered as etiologic or cofactors in odontogenic cysts.
Up to now, limited studies evaluated the presence of this virus in odontogenic cysts and tumors and also their conflicting results made
it hard to conclude. Further studies are needed to make a rational hypothesis related to the role of these viruses in the development
of odontogenic lesions.
Aim: The aim of this study was to evaluate the presence of HPV in odontogenic cysts.
Material & Method: 85 cases of odontogenic cysts from archive of oral and maxillofacial pathology department of Mashhad Dental
School were collected. All cases were deparaffinized and subsequently hydrated and after that DNA was extracted from specimens. By
PCR technique the presence of HPV was evaluated.
Results: 85 odontogenic cysts were evaluated in our study including 20 periapical cysts, 20 dentigerous cysts (DC), 25 calcifying
odontogenic cysts (COC) and 20 odontogenic keratocysts (OKC). Regarding to our results, prevalence of HPV in periapical cyst
were 15%, in OKC 25%, in DC 15%, in COC 24% (Ia 18.18%, Ib 25%, Ic 16.6%, II 50%). Statistical analysis showed that there is a
statistically significant difference regarding to prevalence of HPV only between COC Ia, Ib, Ic types.
Conclusion: According to high prevalence of HPV in odontogenic cysts, we concluded that these viruses may have a role in etiology
and pathogenesis of these lesions.
Biography
Mohammad Amin Khajavi has completed his DMD degree from the Faculty of Dentistry at Mashhad University of Medical Sciences. After working a short time,
he entered the Post-graduate Periodontics Program at Mashhad Dental School. He has published several papers in dental journals and presented at various
conferences.
Mohammad Amin Khajavi, Virol-mycol 2017, 6:2 (Suppl)