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Pediatric White Blood Cell Disorders

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Pediatric white blood cell disorders

Pathophysiology

Body produces white blood cells (leukocytes), which help fight bacterial infections, viruses and fungi. If your child has too few or too many white blood cells, in general, here's what it means: Low white blood cell count (leukopenia) means having too few leukocytes circulating in the blood. A long-term low white blood cell count increases the risk of infections and may be caused by a number of different diseases and conditions. High white blood cell count (leukocytosis) means having too many leukocytes circulating in the blood, usually from having an infection. A number of different diseases and conditions may cause a long-term high white blood cell count.

 
Pediatric white blood cell disorders

Disease statistics

Over the 2-year period, 94 cases were identified. The age-standardised incidence rate of LCH in children aged 0–14 years was 4.1 per million per year. The sex ratio (M:F) was 1.5:1 and the median age at diagnosis was 5.9 years. Single system disease (predominantly bone involvement) accounted for 73% of cases and 27% had multisystem disease of whom 7% had involvement of “risk organs” (liver, lung, spleen and bone marrow). Three children died, two of whom were diagnosed after death.

 
Pediatric white blood cell disorders

Treatment

Treatments for white blood cell disorders depend on several factors, including: The type of disorder, The extent of the disorder, Your child’s overall health, Your child’s response to treatment, Your preferences Our treatments for your child’s white blood cell disorder may include: Chemotherapy, Radiation, Antibiotics, Colony-stimulating factors (these increase the body’s production of blood cells), Drugs to suppress the immune system Stem cell transplantation may be useful for some types of severe white blood cell disorders, particularly those caused by bone marrow problems

 
Pediatric white blood cell disorders

Research

From 1978 to 1988. Patients were followed for an average of 5.2 ± 2.0 years. Age-specific prevalence and incidence rates of CVA in patients with the common genotypes of sickle cell disease were determined, and the effects of hematologic and clinical events on the risk of CVA were analyzed. The highest rates of prevalence of CVA (4.01%) and incidence (0.61 per 100 patient-years) were in sickle cell anemia (SS) patients, but CVA occurred in all common genotypes. The incidence of infarctive CVA was lowest in SS patients 20 to 29 years of age and higher in children and older patients. Conversely, the incidence of hemorrhagic stroke in SS patients was highest among patients aged 20 to 29 years.

 

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