Odontogenic Tumor can be problematic because of recurrence and/or aggressive growth include odontogenic keratocyst (OKC), calcifying odontogenic cyst, and the recently described glandular odontogenic cyst. The OKC has significant growth capacity and recurrence potential and is occasionally indicative of the nevoid basal cell carcinoma syndrome. Prevalence of Odontogenic Tumours in Russia was ameloblastoma (11.7%), followed by odontogenic myxoma (2.2%). When excluded from the list of individual odontogenic tumors, ameloblastoma is the most common (48.5%), followed by odontogenic myxoma (9.2%), adenomatoid odontogenic tumor (7.3%), ameloblastic fibro-odontoma (7.3%), ameloblastic fibroma (6.5%), calcifying odontogenic cyst (6.5%), and odontogenic fibroma (6.1%). Each remaining tumor comprises less than 4%.
Microscopically, squamous odontogenic tumor appears as islands of bland squamous epithelium (no cellular atypia or mitotic figures) without an inflammatory infiltrate. Peripheral palisades are not seen. The epithelial islands are occasionally closely associated with bone spicules. There is superficial resemblance to ameloblastoma (acanthomatous type) and well-differentiated squamous cell carcinoma. Researches focusing on Evaluation of Amelotin Expression in Benign Odontogenic Tumors, Evaluation of Neoplastic Nature of Keratocystic Odontogenic Tumor Versus Ameloblastoma, Immunohistochemical detection of laminin-1 and Ki-67 in radicular cysts and keratocystic odontogenic tumors.