Parkinson’s disease is a degenerative disorder of the motor system in the central nervous system. It is caused due to the death of the dopamine generating cells of the mid brain. Parkinson’s disease is considered a synucleiopathy due to an abnormal accumulation of alpha-syncline protein in the brain in the form of Lewy bodies, as opposed to other diseases such as Alzheimer's disease where the brain accumulates tau protein in the form of neurofibrillary tangles.
Symptoms Symptoms of Parkinson's disease differ from person to person. Parkinson’s disease affects the nerve cells in the brain that produce dopamine. Parkinson’s disease symptoms include muscle rigidity, tremors, and changes in speech and gait. After diagnosis, treatments can help relieve symptoms, but there is no cure.
In Russia Parkinson’s disease was diagnosed using the Webster scale. Fifty two index cases in Moscow, 55 cases in Tashkent, and 27 cases of familial Parkinson’s disease in Lusaka were selected on the basis of the typical clinical features of Parkinson’s disease and a familial history. A total of 49 families and 85 sporadic cases were enrolled in the study.