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Porphyria Catanae Tarda (PCT)
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Porphyria Cutanae Tarda(PCT) is a subtype of porphytic diseases. Porphyria is a disease caused by accumulation of chemical substances called porphyrins. Porphyrins produces heme, which is a vital molecule used to carry oxygen in blood. PCT is characterized by oncholysis (detachment of nail from nail bed) and blistering of skin that is photosensitivities and hyperpigmentation, hypertrichosis also occur. PCT is caused due to deficiency of uroporphyrinogen decarboxylase (UROD).UROD is a cystolic enzyme in enzymatic pathway used in production of heme. Therefore deficiency of UROD enzyme leads to this disorder. It can also be inherited. There are two types of PCT:
Type-1 (sporadic): Here UROD deficiency is seen only in hepatic cells and HFE deficiency also plays a major role.
Type-2 (familial): It is deficiency of UROD gene in a dominant pattern in individuals.
Type-3: It is a least common type, where patients indicate unrelated expression of genetic component of UROD.
Therefore it is treated with low doses of antimalarials to remove excess of porphyrins from liver and chloroquine, hydroxychloroquine are typically employed.
Related Journals of Porphyria Cutanae Tarda(PCT)
Psoriasis & Rosacea Open Access, Clinical Pediatrics & Dermatology, Journal of Clinical & Experimental Dermatology Research, Dermatology Case Reports, Journal of Dermatitis, Archives of Dermatology, JDDG - Journal of the German Society of Dermatology, Journal of Clinical and Aesthetic Dermatology, Journal of Clinical Dermatology, Journal of Cosmetic Dermatology, Journal of Dermatology, Journal of Drugs in Dermatology