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Progeria

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Progeria We know that there is a biological overlap between children with Progeria and the general aging population. We all make a little bit of progerin, the disease-causing protein in Progeria. We make much less progerin than children with Progeria, but the progerin builds up over a lifetime and may be partly responsible for aspects of aging such as atherosclerosis. Progerin is also linked to telomere dysfunction. Telomeres are proteins that play a major role in cellular aging.
 
Progeria

Therapeutic aspects

No treatment has demonstrated successful. Most treatment focuses on lessening intricacies, (for example, cardiovascular infection) with corocoronary artery bypass surgery or low-doseaspirin. Children might likewise profit by a high-vitality diet. Development hormone treatment has been endeavored. The utilization of Morpholinos has additionally been endeavored so as to lessen progerin generation. Farnesyltransferase inhibitors (FTIs) are medications that restrain the movement of a chemical required with a specific end goal to make a connection between progerin proteins and farnesyl bunches. Pravastatin, exchanged as Pravachol or Selektine, is incorporated into the group of statins. And additionally zoledronate (otherwise called Zometa and Reclast, which is a bisphosphonate), its utility in HGPS is the counteractive action of farnesyl gathering arrangement, which progerin needs to provoke the disease.

 
 

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