alexa Acute Lung Injury | Journal of Pulmonary and Respiratory Medicine

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Acute Lung Injury

Acute Lung Injury (ALI) is a unique type of acute respiratory problem described as acute extreme hypoxia that is not because of left atrial hypertension.

There are two manifestations of ALI:

• Primary ALI brought about by immediate harm to lung. E.g., pneumonia, aspiration

• Secondary ALI is brought about by roundabout damage to lung. E.g., pancreatitis, severe sepsis

There are two major stages – the acute phase portrayed by disturbance of the alveolar-hair interface, spillage of protein rich liquid into the interstitium and alveolar space and impressive arrival of cytokines and movement of neutrophils. A later reparative stage is described by fibroproliferation, and association of lung tissue.

Treatment: The foundation of medication is to keep the Pao2 >60mmhg, without initiating damage to the lungs with extreme O2 or volutrauma. Pressure control ventilation is more versatile than volume control, in spite of the fact that breaths ought to be volume constrained, to counteract extend harm to the alveoli. In general tidal volumes should not exceed 6ml/kg and pressure should not exceed 30cmH2O. However, tidal volumes of 4ml/kg should be delivered irrespective of airway pressure.

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