Sclerosing mesenteritis is a rare spectrum of disease characterized by degeneration (necrosis), inflammation and scarring (fibrosis) of fatty (adipose) tissue of the mesentery. Symptoms: sclerosing mesenteritis is asymptomatic, gastrointestinal symptoms such as abdominal pain, nausea/vomiting, bloating, loss of appetite, weight loss and diarrhea or constipation, Occasionally, intermittent partial bowel obstruction is encountered. Non-gastrointestinal symptoms include fatigue, weight loss, night sweats and fever.
Glucocorticoid drugs such as prednisone, which relieve inflammation. They may be used in combination with azathioprine and colchicine.Hormonal therapy such as tamoxifen has also been shown to work. Sometimes hormonal therapy is used together with glucocorticoid drugs.Several other medications such as azathioprine, colchicine, Cyclophosphamide and thalidomide.
History of sclerosing mesenteritis is not well understood, because of the rarity of this condition. In a five-year follow-up report of 47 patients with mesenteric Sclerosing mesenteritis, 65 percent were alive, and in those who died, one-half of the deaths were due to malignancy (50 percent carcinoma, 50 percent lymphoma) In another series, 12 percent of patients developed malignancy, including lymphoma, carcinoid syndrome, lung adenocarcinoma, and mesothelioma. Fulminant cases of sclerosing mesenteritis have been reported and are largely due to complications of intestinal obstruction.