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Membranous Nephropathy

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  • Membranous nephropathy

     

    Membranous nephropathy is a kidney disorder that leads to changes and inflammation of the structures inside the kidney that help filter wastes and fluids. The inflammation may lead to problems with kidney function. 

  • Membranous nephropathy

    Disease pathophysiology: 

    Neutral endopeptidase, a podocyte antigen that can digest biologically active peptides, was recently identified as the target antigen of antibodies deposited in the subepithelial space of glomeruli in a subset of patients with antenatal membranous nephropathy.

     

  • Membranous nephropathy

    Disease statistics:

    Membranous nephropathy (MGN) is one of the more common forms of nephrotic syndrome in the adult population. It can be idiopathicor secondary (30%). The two can be distinguished by clinical, laboratory, and histological features.

     

  • Membranous nephropathy

    Disease treatment:

    Diuretics help control edema. Loop diuretics are used most often.NSAIDs help to decrease the proteinuria. These have been largely supplanted by angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs). ACE inhibitors decrease proteinuria and control hypertension; use ARBs for patients intolerant of ACE inhibitors. Hepatic 3-methylglutaryl coenzyme A reductase inhibitors help treat hypercholesterolemia.

     

  • Membranous nephropathy

    Major research on disease:

    A low-salt diet is key to reducing anasarca. Protein restrictions may or may not be useful in reducing the rate of progression of chronic renal failure. Boston Team Developing PLA2R Antibody Test for Membranous Nephropathy.

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