A muscle cramp is also known as charley horse. It is a strong, painful contraction of legs or that comes on suddenly and lasts from a few seconds. It often occurs in the legs. The causes of muscle cramps are because of decreased amounts of minerals like calcium and magnesium, especially in the later months of pregnancy and Exposure to cold temperatures. Quinine is very effective in preventing muscle cramps.
Night time calf cramps typically woke sufferers from sleep, affected either leg and caused ongoing pain. Most participants experienced little or no relief with current therapies used to prevent muscle cramp. Most people who were taking quinine for muscle cramp were unaware that the Australian Therapeutic Goods Administration withdrew support of quinine for muscle cramp in 2004 due to the risk of thrombocytopaenia. Case-control studies are required to identify therapeutic targets so that clinical trials can evaluate safe interventions to prevent recurrent cramp.