Nasal polyps (NP) are common benign degeneration of nasal sinus mucosa which are mostly associated with chronic inflammations due to allergy, infection, asthma and aspirin sensitivity. From as low as 4% of patients with polyps having asthma to as high as 40% with most studies showing approximately 33%. The estimates of aspirin intolerance in nasal polyps also vary from 4-26%. Corticosteroids are the treatment of choice, either topically or systemically.
Direct injection into the polyp is not approved by the US Food and Drug Administration (FDA) because of reports of unilateral vision loss in 3 patients after intranasal steroid injection with Kenalog. Patients presenting with chronic rhinitis with polyps are found to have oedema of the nasal mucosa, low T regulator cell activity and low levels of beta-tissue growth factor. The opposite picture is seen with patients who have chronic rhinitis without polyps.