alexa Fibrous Dysplasia | Brazil| PDF | PPT| Case Reports | Symptoms | Treatment

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Fibrous Dysplasia

  • Fibrous Dysplasia


    Fibrous dysplasia is an uncommon bone disorder characterized by an abnormal bone growth where normal bone is replaced with fibrous bone tissue. This can cause deformation and fracture of the bones. It is non-neoplastic tumor-like congenital process.

  • Fibrous Dysplasia


    Fibrous dysplasia is linked to a gene mutation that affects the cells that produce bone. The medullary cavity of bones is filled with fibrous tissue, causing the expansion of the areas of bone involved. The bony trabeculae are abnormally thin and irregular in shape. The cause of this may be linked to transcription factor C-fos. The activity of C-fos increases, leading to over expression of the gene, and hence tumor formation.

  • Fibrous Dysplasia


    Usually, no treatment is required as the bone lesions usually do not progress beyond puberty. As for drugs, pain killer and supplements are given. In severe cases surgery is preferred.Fibrous Dysplasia Treatment. Surgery may be necessary for more problematic cases of fibrous dysplasia involving chronic pain, fractures, or deformity.

  • Fibrous Dysplasia


    In the fibrous dysplasia archives of the Department of Radiologic Pathology at the Armed Forces Institute of Pathology (AFIP) , there is an a!- most 2 : 1 male predominance in 427 patients with the monostotic variant. Fibrous dysplasia of bone is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This disease usually affects children and young adults.

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