alexa X-linked agammaglobulinemia | Canada| PDF | PPT| Case Reports | Symptoms | Treatment

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X-linked Agammaglobulinemia

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  • X-linked agammaglobulinemia


    X-linked agammaglobulinemia (XLA), or Bruton agammaglobulinemia, is an inherited immunodeficiency disease caused by mutations in the gene coding for Bruton tyrosine kinase (BTK). BTK is critical to the maturation of pre B cells to differentiating mature B cells.

  • X-linked agammaglobulinemia

    Treatment of X-linked agammaglobulinemia

    No curative therapy exists for X-linked agammaglobulinemia (XLA), or Bruton agammaglobulinemia. Treatment for XLA is IVIG. Typical doses are 400-600 mg/kg/mo given every 3-4 weeks. Doses and intervals can be adjusted based on individual clinical responses. Therapy should begin at age 10-12 weeks. Maintenance of an IgG trough level of 500-800 mg/dL is recommended. Therapy should be started at age 10-12 weeks. Currently, no evidence supports that one particular brand or route of administration (IV vs SC) is better than the other.

  • X-linked agammaglobulinemia

    Major Research on X-linked agammaglobulinemia in Canada

    The research being carried out throughout the country can be stated as Computerized Patient Phenotyping to Connect Canadian Clinical Genetics Clinics.

  • X-linked agammaglobulinemia

    Disease Statistics of X-linked agammaglobulinemia

    The disease statistics can be observed as 32,507,874 of the total population are prone to the disease.


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