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conferenceseries
.com
Volume 9
Chemical Sciences Journal
Asia Chemistry 2018
September 12-13, 2018
11
th
Annual Congress on
September 12-13, 2018 Singapore
Chemistry
Galactofuranose-based compounds as potential inhibitors of GlfT1
Benice Lyrem Joy S Lim
1
, Completo Gladys Cherisse J
1
, Tabilog Andrew Exequiel S
1
, Allas Mikel Jason D G
1,2
, Angkico Rowin Christian B
2
, Espejo Jaevee
William T
2
, Sumalde Jan Michael C
2
, Joe Maju
3
, Zheng Blake
3
and Lowary Todd L
3
1
University of the Philippines-Los Baños, Philippines
2
De La Salle University, Philippines
3
University of Alberta, Canada
T
he enzyme Galactofuranosyltransferase 1 (GlfT1), initiates the elongation of the Galactan chain of the mycolyl-
Arabinogalactan Peptidoglycan (mAGP) complex of the mycobacterial cell wall. mAGP is essential for the microorganism’s
viability and its Galactan chain backbone is comprised of alternating 5- and 6-linked β-D-Galactofuranose (Galf) units that
are not found in humans and thus, enzymes (e.g. GlfT1) involved in its biosynthesis might serve as putative therapeutic targets
in diseases such as tuberculosis. Several potential inhibitors resembling the polysaccharide glycan were synthesized and tested
against GlfT1.
Biography
Benice Lyrem Joy S Lim is a MS Chemistry student at the University of the Philippines Los Baños. She works as a Research Associate in the laboratory of Dr.
Gladys Cherisse J Completo. Her field of interests involves synthetic and Natural products chemistry.
bslim@up.edu.phBenice Lyrem Joy S Lim et al., Chem Sci J 2018, Volume 9
DOI: 10.4172/2150-3494-C5-030