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Volume 9 Chemical Sciences Journal Asia Chemistry 2018
September 12-13, 2018
11th Annual Congress on
September 12-13, 2018 Singapore Chemistry
Construction of an Electrochemical sensor based on Carbon nanotubes/Gold nanoparticles for trace
determination of Amoxicillin in bovine milk
Aliyu Muhammad1, 2, Nor Azah Yusof2, Reza Hajian2 and Jaafar Abdullah2
1Kebbi State University of Science and Technology Aliero, Nigeria
2Universiti Putra Malaysia, Malaysia
Inthiswork, anovel electrochemical sensorwas fabricatedfordeterminationof amoxicillininbovinemilksamplesbydecoration
of carboxylated Multi-Walled Carbon Nanotubes (MWCNTs) with gold Nanoparticles (AuNPs) using ethylenediamine (en)
as a cross linker (AuNPs/en-MWCNTs). The constructed nanocomposite was homogenized in dimethylformamide and drop
casted on screen printed electrode. Field Emission Scanning Electron Microscopy (FESEM), Energy Dispersive X-Ray (EDX),
X-Ray Diffraction (XRD) and cyclic voltammetry were used to characterize the Synthesized Nanocomposites. The results show
that the synthesized nanocomposites induced a remarkable synergetic effect for the oxidation of amoxicillin. Effect of some
parameters, including pH, buffer, scan rate, accumulation potential, accumulation time and amount of casted nanocomposites,
on the sensitivity of fabricated sensor were optimized. Under the optimum conditions, there was two linear calibration ranges
from 0.2-10 µM and 10-30 µM with equations of Ipa (µA)=2.88C (µM)+1.2017; r=0.9939 and Ipa (µA)=0.88C (µM)+22.97;
r=0.9973, respectively. The Limit of Detection (LOD) and Limit of Quantitation (LOQ) were calculated as 0.015 µM and 0.149
µM, respectively. The fabricated electrochemical sensor was successfully applied for determination of Amoxicillin in bovine
milk samples and all results compared with High Performance Liquid Chromatography (HPLC) standard method.
Chem Sci J 2018, Volume 9
DOI: 10.4172/2150-3494-C5-030