biochemistry-2016_scientifictracks-abstracts

10 / 16

Volume 5, Issue 3(Suppl) Biochem Anal Biochem 2016
ISSN: 2161-1009, Biochem an open access journal
Page 31
Notes:
Biochemistry 2016
October 10-12, 2016
conferenceseries.com
Biochemistry
October 10-12, 2016 Kuala Lumpur, Malaysia
International Conference on
Intestinal fatty acid binding protein Ala54Thr polymorphism is associated with peripheral atherosclerosis
combined with type-2 diabetes mellitus
Eman T Mehanna
Suez Canal University, Egypt
The intestinal fatty acid binding protein (FABP-2) is expressed in enterocytes and binds with saturated and unsaturated long-chain
fatty acids. FABP-2 Ala54Thr polymorphism was reported to have an influence on lipid metabolism. This study aimed to assess
the relation of this polymorphism with peripheral atherosclerosis combined with type 2 diabetes mellitus in an Egyptian population.
The study included 100 diabetic patients with peripheral atherosclerosis and 100 control subjects. The Ala54Thr polymorphism was
analyzed by PCR-RFLP. FABP-2 level was measured by ELISA technique. FBG, fasting serum insulin, HbA1c lipid profile, BMI,
systolic and diastolic blood pressure were all determined. The Thr54 allele had higher frequency among the patients group (p=0.002).
The heterozygote Ala54/Thr54 and the rare Thr54/Thr54 genotypes showed significant increase in BMI and FABP-2. Carriers of
Thr54/Thr54 genotype had significantly decreased HDL-C. Carriers of Thr54/Thr54 genotype had significantly higher systolic and
diastolic blood pressure than carriers of both Ala54/Ala54and Ala54/Thr54 genotypes. FABP-2 level had positive correlationwith BMI,
systolic and diastolic blood pressure and negatively correlated with HDL-C. The Thr54 allele of FABP-2 Ala54Thr polymorphism was
associated with increased incidence of peripheral atherosclerosis combined with type-2 diabetes mellitus in the studied population.
Biography
Eman T Mehanna is a Lecturer of Biochemistry and Molecular Biology at the Faculty of Pharmacy, Suez Canal University, Egypt. She has 6 internationally published papers.
Eman T Mehanna, Biochem Anal Biochem 2016, 5:3(Suppl)