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Volume 5, Issue 3(Suppl) Biochem Anal Biochem 2016
ISSN: 2161-1009, Biochem an open access journal
Page 38
Notes:
Biochemistry 2016
October 10-12, 2016
conferenceseries.com
Biochemistry
October 10-12, 2016 Kuala Lumpur, Malaysia
International Conference on
Nano-magnetite L-proline as an efficient nano-biocatalyst for the synthesis of tetrahydrobenzo[b]pyran
derivatives
Ali Ramazani and Hamideh Aghahosseini
University of Zanjan, Iran
L-proline is known as the most favored catalyst in enamine-mediated reactions. This simple amino acid as a bifunctional catalyst
is efficiently applied in variety of organic transformations. The simplicity of this small molecule contrasts with the complex
structure of the natural enzymes, which are capable of promoting similar transformations. A secondary amine, functionality refers to
its enhanced nucleophilicity over the other amino acids, which is the particular feature in nucleophilic catalysts. From the catalytic
performance point of view, proline is termed “the simplest enzyme”, meanwhile it is a building block or catalytic center of some of
natural enzymes. The surprising versatility and specificity of this simple natural amino acid against toxic organometallic catalysts
convert it to a promising candidate for artificial enzyme designing. Magnetic functionalization of L-proline gives recoverability and
reusability to this efficient organocatalyst. Herein, we report the synthesis and use of magnetite L-proline as an efficient and reusable
nano-biocatalyst in the coupling reaction of dimedone, malononitrile and aromatic aldehydes to afford the corresponding benzo-[b ]-
pyran derivatives in aqueous media and in good yields. Pyran derivatives have great biological and pharmacological importance that
is organized as a significant class of heterocyclic compounds. Despite the catalytic role of proline in chemical reactions, it has been
known for several decades, but its significance in biochemistry and biogenesis has still remained uncovered.
Biography
Ali Ramazani has completed his PhD under the supervision of Professor Issa Yavari in the Department of Chemistry at the Tarbiat Modares University (TMU), Iran. He
currently works as a Full Professor in Chemistry at the University of Zanjan, Iran. His studies focused on Organic Synthesis and Nanochemistry. He has published more than
350 papers and is an Editorial Board Member of the international journal Nanochemistry Research. He has received several national and international awards, including the
2013 Khwarizmi International Award, Several Top-Cited Author Awards and Best-Paper Awards from leading ISI Journals, Best Researcher Awards and the Best Lecturer
Awards at the University of Zanjan.
Ali Ramazani et al., Biochem Anal Biochem 2016, 5:3(Suppl)