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Chromatography 2016
September 21-23, 2016
Volume 7, Issue 5(Suppl) J Chromatogr Sep Tech 2016
ISSN: 2157-7064 JCGST, an open access journal
conferenceseries .com
September 21-23, 2016 Amsterdam, Netherlands
World Congress on Chromatography
Separation of drug active ingredients by using subcritical water chromatography
Berkant Kayan1, Sema Akay1 and Yu Yang2
1Aksaray University, Turkey
2East Carolina University, USA
Drug active ingredients contain one or more chemical substances that cause physiological changes in vivo and substances
that are responsible for the beneficial health effects experienced by patients. Drugs are usually grouped according to
their physiological effects and antidepressants are one of the most frequently used of this group. In this study, fluoxetine and
sertraline are used as selected model molecules obtained from antidepressant active agent, which have environmental as well
as pharmacological and biological importance. For this purpose, naphthylamine attached poly (HEMA-MAH)(PHEMAH)
(poly(hydroxyethyl methacrylate-N-methacryloyl-(L-histidine)-methylester) microspheres, which have different particle sizes
will be synthesized and used as the column filling material (stationary phase) in high temperature liquid chromatography which
is one of the green chromatography techniques and determination of the method development and optimization conditions
for the synthesized column filler will be conducted by using chemometrics application of response surface methodology.
Many analytical methods such as High Performance Liquid Chromatography, Liquid Chromatography-Mass Spectrometry/
Mass Spectrometry, Gas Chromatography-Mass Spectrometry are used in literature for the chromatographic separation
of the active ingredients of antidepressants. Among the used techniques, the High Performance Liquid Chromatography
(HPLC) shows the most effective separation technique. While RPLC (Reversed Phase Liquid Chromatography) is a popular
analytical technique used today, organic solvents are required in traditional RPLC and an enormous amount of organic solvent
is consumed worldwide for just chromatographic separation. The organic solvents used in HPLC are very hazardous and
dangerous for environmental and human health, as well as expensive in term of both purchasing and waste disposal costs.
Industrial wastewater pollution is being one of the major and perhaps most importantly problem resulting from uncontrolled
technology in developing countries. Therefore, separation, purification and determination methods are more important and
“nature-friendly” products and dissemination of related researchers is of great importance for use as solid/solid phase of
determination methods due to environmental concerns. High temperature liquid water chromatography technique used the
minimum level of organic solvent in which worldwide attention has been obtained recently. At the same time, in order to be
successful in the separation process in HTLC, new generation of stable and resistant filler column is synthesized and is also
an important application which is successful at elevated temperature conditions. The systematic studies are rapid, accurate, is
expected to reach accurate and reliable results as the requirement of a scientific research.
Biography
Berkant Kayan is an Associate Professor of Chemistry, Aksaray University, Aksaray, Turkey. He has joined Aksaray University in 2009 as Assistant Professor and
then quickly promoted to the Associate Professor position in 2012. He has 18 publications and research grants and projects from Scientific and Technological
Research Council of Turkey - TUBITAK, Aksaray University-ASU-BAP-2012-9, and Mersin University- MERSIN-BAP. He joined the Department of Chemistry at
East Carolina University in 2005 as visiting doctoral student for four months which was supported by Mersin University. He visited Technological and Educational
Institute of Crete, Chania, Crete, Greece (2013) and Université Paris-Est Marne-la-Vallée., Paris, France (2015) with European Erasmus Bilateral as Guest
Academic Researcher.
Berkant Kayan et al., J Chromatogr Sep Tech 2016, 7:5(Suppl)