traditional-medicine-2016_posters-accepted-abstracts

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Volume 5, Issue 2 (Suppl) J Tradi Med Clin Natur
ISSN: JTMCN, an open access journal
Page 70
Notes:
Traditional Medicine 2016
September 14-16, 2016
conferenceseries.com
September 14-16, 2016 Amsterdam, Netherlands
6th International Conference and Exhibition on
Traditional & Alternative Medicine
Aman Tedasen et al., J Tradi Med Clin Natur 2016, 5:2 (Suppl)
5′-desmethoxyyatein: Potential key inhibitor of proteins for cancer inhibition
Aman Tedasen, Varomyalin Tipmanee and Potchanapond Graidist
Prince of Songkla University, Thailand
5'-desmethoxyyatein, a natural lignan, has shown potent cytotoxic activity in many cancer cell lines including melanoma, leukemia,
breast, colon and brain cancers. Molecular docking is a powerful computational tool to predict the binding mode and binding
affinity of a ligand with the specific proteins. In this study, we aimed to investigate molecular targets of 5'-desmethoxyyatein from 80
proteins, which relate to cancer cell proliferation, cell cycle progression, apoptosis, or cell migration. Binding affinity evaluation of
5'-desmethoxyyatein to these proteins was carried out using Molecular docking method. Results showed that 5'-desmethoxyyatein
may inhibit activin receptor 2 (ACTVR2), prostaglandin G/H synthase 2, human epidermal growth factor receptor 2 (HER-2), janus
kinase 3 (JAK3), protein kinase C (PKC), heat shock protein 90-beta (Hsp90-beta), transforming growth factor receptor I (TGF-β
receptor I), androgen receptor and NF-kappa-B-inducing kinase (NIK) proteins. This information was derived from better predicted
binding affinity of 5'-desmethoxyyatein, compared to its known inhibitors. Moreover, 5'-desmethoxyyatein may hinder cell cycle
progression via binding to cyclin A, polo-like kinase 1 (PLK1) and aurora A proteins with binding energy and inhibition constant
lower than its known inhibitors. X-linked inhibitor of apoptosis protein (XAIP) and glycogen synthase kinase 3 (GSK-3β) proteins,
involved in apoptosis and migration in cancer cells, also may better interact with 5'-desmethoxyyatein than their inhibitors. This
study suggests 5'-desmethoxyyatein would be anti-tumor agent with anti-proliferation, cell cycle arrest inducing, apoptosis induction
and anti-migration activities. However, further studies such as Western blot analysis are needed.
Biography
Aman Tedasen is a PhD student at Department of Biomedical Sciences, Faculty of Medicine, Prince of Songkla University, Thailand. He received his Medical
Technology training and earned his Bachelor’s degree in 2012. He received a scholarship from the Royal Golden Jubilee PhD Program of Thai government. His
research interest has focused on developing effective treatment strategies from herbal medicine for breast cancer.