traditional-medicine-2016_posters-accepted-abstracts

Volume 5, Issue 2 (Suppl)

J Tradi Med Clin Natur

ISSN: JTMCN, an open access journal

Page 73

Notes:

Traditional Medicine 2016

September 14-16, 2016

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September 14-16, 2016 Amsterdam, Netherlands

International Conference and Exhibition on

Traditional & Alternative Medicine

Ilham M O Ahmed et al., J Tradi Med Clin Natur 2016, 5:2 (Suppl)

Toxicological effects of

Ambrosia maritima

in Nubian goats

Ilham M O Ahmed

, Mohammed A S

, Halima M O

and

Ibtehal M A Ahmed

Veterinary Research Institute, Sudan

University of Khartoum, Sudan

oxicity of indigenous plant

Ambrosia maritima

was investigated. Twenty four, 6-8 month old, 12 female and 12 male of Sudanese

Nubian goats were used. Dried leaves powder of

Ambrosia maritima

was mixed with water and given orally by drench to the

animals at a dose of 1000 or 2000 mg/kg/day for 126 days. Two females drenched the plant at a dose of 1000 mg/kg/day, were died at

day 8 and 9 post treatment and one female drenched the plant at a dose of 2000/kg/day died at day 13. The results revealed that goats

drenched the plant for 126 days, showed chronic toxicity evident by clinical symptoms, pathological and biochemical changes.Themain

symptoms were watery diarrhea, inappetance, respiratory distress and depression. Later these symptoms disappeared and the animals

appeared healthy. The most evident pathological features were hydrothorax, hydropretonium, hydropericardium, and enlargement

of the liver. Histopathological changes were exemplified by degeneration and necrosis of the hepatic cells. Focal necrosis, congestion

and haemorrhag of proximal convoluted tubules, Necrosis of intestinal vili with severe infiltration of inflammatory cells, congestion

of alveolar capillaries and pancreatic hyperplasia all these changes were correlated to the activity of Asparate Aminotransferase (AST),

Alkaline phosphate (ALP), the concentration of cholesterol, sodium and potassium in the serum, and with the hematological values.

The effect of the plant on males was less marked compared to that on female goats. There was gradual increase in mean body-weight

of both sexes.