traditional-medicine-2016_posters-accepted-abstracts

Volume 5, Issue 2 (Suppl)

J Tradi Med Clin Natur

ISSN: JTMCN, an open access journal

Page 76

Notes:

Traditional Medicine 2016

September 14-16, 2016

conferenceseries

.com

September 14-16, 2016 Amsterdam, Netherlands

International Conference and Exhibition on

Traditional & Alternative Medicine

Naglaa Gamil Shehab et al., J Tradi Med Clin Natur 2016, 5:2 (Suppl)

http://dx.doi.org/10.4172/2167-1206.C1.003

Micromeria fruticosa

(L.) Druce ssp

Serpyllifolia

: Constituents, Antimicrobial and Evaluation of Burn

Healing Activity of the Extract and its IsolatedActive Constituents in Topical Formulation

Naglaa Gamil Shehab

and

Eman Abu-Gharbieh

Cairo University, Egypt

Dubai Pharmacy College, UAE

icromeria fruticosa

(L) Druce ssp

serpyllifolia

is widely used in the Mediterranean regions in treatment of various inflammatory

conditions and in wound healing. The purpose of this study was to investigate the constituents of the ethanolic extract of

Micromeria fruticosa

(L.), to evaluate the antimicrobial and the burn healing activities of the extract, its fractions and its isolated

compounds and to formulate, characterize and evaluate natural burn-healing topical preparations containing the crude plant extract

or the isolated compounds. The LD

of the ethanolic extract (up to 4 g/kg) indicated its safety. The growth inhibitory activity of the

ethanolic extract, and its hexane, chloroform, and

-butanol fractions as well the isolated compounds was evaluated

in-vitro

against

a set of micro-organisms. The isolated compounds from the chloroform and

-butanol fractions were belonging to flavonoids and

triterpenes. The ethanolic extract as well its fractions, hexane, chloroform and butanol exhibited variable antimicrobial activities

comparable to broad spectrum antibiotic gentamycin used as control. These effects could be attributed to the isolated flavonoids

and triterpenes compounds. Burn healing potentiality of the ethanolic extract was also explored against the commercial product

and found noticeably significant. Histopathological analysis showed sever endodermal, columnar basal cells and sebaceous gland

damage in the untreated burnt animals whereas treated animals showed significant reduction in wound size and improvement in the

histological finding. Besides, from the in vivo burn healing and histological results, the topical formulae enhanced the skin wound

re-epithelialization and speed up the healing process.

Biography

Naglaa Gamil Shehab has graduated from Faculty of Pharmacy, Cairo University, Egypt and has received the PhD from Department of Pharmocognosy, Faculty of

Pharmacy, Cairo University, Egypt. She has received the best Master thesis from Egypt and the best research award from Saudi Arabia. Currently, she is working

as Associate Professor at Pharmocognosy Department, Faculty of Pharmacy, Cairo University, Egypt. She is member in American Society of Pharmocognosy and

also reviewer for many international journals. Her interesting field is in the bioactivity of medicinal plants. She published about 25 papers in international journals.

Naglaa_shehab@hotmail.com