Naegleria infection is a rare and usually fatal brain infection caused by an amoeba commonly found in freshwater lakes, rivers and hot springs. Exposure occurs during swimming or other water sports. travels up the nose to the brain, where it causes severe damage. Naegleria infections may also occur when contaminated water from other sources.
The most distressing aspect is that the fatality rate has remained more than 95%. there have been 133 PAM infections from 1962 through 2014 with only three survivors. Free-living pathogenic amoebae of the species Naegleria fowleri are responsible for primary amoebic meningo-encephalitis (PAM), a rare disease with a fatality rate of 95%. In fact, of the 310 cases of the disease that have been reported worldwide
The primary treatment for naegleria infection is an antifungal drug, amphotericin B. An investigational drug called miltefosine (Impavido) is now available for emergency treatment of naegleria infection. Other drugs are clotrimazole, itraconazole, fluconazole, and ketoconazole, with varying degrees of efficacy.The macrolide antibiotic azithromycin is effective against Naegleria species in vitro and in murine models.