Hepatic excretory capacity is low both because of low concentrations of the binding protein ligandin in the hepatocytes and because of low activity of glucuronyl transferase, the enzyme responsible for binding bilirubin to glucuronic acid, thus making bilirubin water soluble (conjugation). Approximately 65% of newborn infants develop clinically evident jaundice in the first week of life (Maisels 1992).
Phototherapy is treatment with light. It is used in some cases of newborn jaundice to lower the bilirubin levels A blood transfusion, known as an exchange transfusion, may be recommended if your baby has particularly high levels of bilirubin Breastfeeding rates following the discharge of infants diagnosed with jaundice were not significantly different from those reported for the general population. Larger prospective studies in diverse populations are needed to determine the rates of early breastfeeding discontinuation in jaundiced infants.