Common symptoms of HCL includes persistently feeling tired, weakness, weight loss for no reason, shortness of breath, excessive sweating (most often at night), swollen lymph nodes, frequent infections and fevers, small red spots on the skin. The main treatment for hairy cell leukemia is chemotherapy, purine analog drugs either cladribine (2-CdA) or pentostatin, monoclonal antibody rituximab, surgery or interferon alpha.
Abdominal discomfort is a common symptom, resulting from hepatosplenomegaly. It is usually controlled with new effective drug therapy, although late recurrences may occur. Recurrences are usually responsive to medications. The prognosis and relapse rates of 60–80% will survivie for 5–10 years after diagnosis.