Odontogenic infections, consisting primarily of dental caries and periodontal disease (gingivitis and periodontitis), are common and have local (eg, tooth loss) and, in some cases, systemic implications. The prevalence of odontogenic and nonodontogenic cysts in Israel was 3.51%; males were affected more frequently than females. There were 452 odontogenic cysts (98.5%) and seven nonodontogenic cysts (1.5%). The most frequent odontogenic cyst was radicular (54.7%), followed by dentigerous (26.6%), residual (13.7%), odontogenic keratocyst (3.3%), and lateral periodontal cyst (0.2%). Nasopalatine duct cyst (1.5%) was the only nonodontogenic cyst.
Microscopically, squamous odontogenic tumor appears as islands of bland squamous epithelium (no cellular atypia or mitotic figures) without an inflammatory infiltrate. Peripheral palisades are not seen. The epithelial islands are occasionally closely associated with bone spicules. There is superficial resemblance to ameloblastoma (acanthomatous type) and well-differentiated squamous cell carcinoma. Computerized tomography findings and recurrence of keratocystic odontogenic tumor, Alpha-smooth muscle actin within epithelial islands is predictive of ameloblastic carcinoma, Features of odontogenesis and expression of cytokeratins and tenascin-C in three cases of extraosseous and intraosseous calcifying odontogenic cyst.