Sclerosing mesenteritis occurs when the tissue (mesentery) that holds the small intestines in place becomes inflamed and forms scar tissue. Sclerosing mesenteritis is rare, and it's not clear what causes it.
Includes abdominal surgery or trauma , autoimmunity , paraneoplastic syndrome, ischaemic injury and infection.small bowel mesentery is affected in most cases although the sigmoid mesocolon and omentum can also be occasionally be involved.The disease includes three stages. Stage-1: mesenteric lipodystrophy, degeneration of mesenteric fat. Stage-2: mesenteric panniculitis, inflammatory reaction. Stage-3: retractile mesenteritis / sclerosing mesenteritis, fibrosis, which may be associated with distortion or lymphatic obstruction.
Tests and procedures used to diagnose sclerosing mesenteritis include.There is considerable overlap between these inflammatory conditions often leading to diagnostic and therapeutic confusion. 1. Physical exam: sclerosing mesenteritis often forms a mass in upper abdomen that can be felt during a physical exam. 2. Imaging tests: Imaging tests of your abdomen may reveal sclerosing mesenteritis. Imaging tests may include computerized tomography or magnetic resonance imaging. 3. Biopsy: Removing a sample of tissue for testing.
Fewer than 200 cases have been reported in the literature.Glucocorticoid drugs such as prednisone, which relieve inflammation. They may be used in combination with azathioprine and colchicine.Hormonal therapy such as tamoxifen has also been shown to work. Sometimes hormonal therapy is used together with glucocorticoid drugs.Several other medications such as azathioprine, colchicine, Cyclophosphamide and thalidomide.