While chemotherapy, radiation therapy, curettage and liquid nitrogen have been effective in some cases of ameloblastoma, surgical resection or enucleation remains the most definitive treatment for this condition. In a detailed study of 345 patients, chemotherapy and radiation therapy seemed to be contraindicated for the treatment of ameloblastomas.
There is evidence that suppression of matrix metalloproteinase-2 may inhibit the local invasiveness of ameloblastoma, however, this was only demonstrated in vitro. There is also some research suggesting that α5β1 integrin may participate in the local invasiveness of ameloblastomas.
The chi-square test for differences between the two groups and the Analysis of Variance Ameloblastoma is a rare disorder that affects males and females in equal numbers. It affects persons of all ethnic backgrounds and of all age groups. (ANOVA) test for differences among three or more groups was used. The level of statistical significance was set at P < 0.05. The case records and surgical biopsy reports of all diagnosed cases of ameloblastoma archived from January 2010 to December 2012 were retrieved from the Outpatient Department of Oral Medicine and Radiology, Vishnu Dental College, Bhimavaram, West Godavari District, Andhra Pradesh.