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Membranous Nephropathy

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  • Membranous nephropathy


    Membranous nephropathy
     (MN) accounts for most cases of the nephrotic syndrome in adults. Membranous nephropathy is characterized by diffuse thickening of the glomerular capillarybasement membrane by subepithelial immune complex deposition. Membranous glomerulonephritis (MGN) is a slowly progressive disease of the kidney affecting mostly patients between ages of 30 and 50 years

  • Membranous nephropathy

    Disease pathophysiology: 

    The damage and increased permeability of the basement membrane to plasma proteins and hence nephrotic rangeproteinuria. Thickening of the peripheral capillary loops, 'spikes' and 'craters' on silver- and PAS-stained sections Proximal tubules may contain prominent protein reabsorption granules The interstitium is usually delicate; foamy macrophages may be seen on rare occasions.

  • Membranous nephropathy

    Disease statistics:

    All patients with abnormal urine findings and/or decreasing renal function of unknown cause were referred for renal biopsy between October 2002 and December 2008. The drop-out rate is assumed to be less than 5%. All biopsies were analysed according to international standards and traditional epidemiological and clinical parameters were collected for comparison with the micro-census of the year 2008. 

  • Membranous nephropathy

    Disease treatment:

    Controlling blood pressure is the most important way to delay kidney damage. The goal is to keep blood pressure at or below 130/80 mmHg. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are the medicines most often used to lower blood pressure. Corticosteroids and other drugs that suppress the immune system may be used. 

     

  • Membranous nephropathy

    Major research on disease: 

    Mechanical research on effects of yishenqing on membranous nephropathyThromboembolic complications in membranous nephropathy patients with nephrotic syndrome-a prospective study. Assessing the results of a therapy from uncontrolled studies is very difficult in a disease with a variable outcome such as IMN. 

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