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Membranous Nephropathy

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  • Membranous nephropathy


    Membranous glomerulonephritis
     
    (MGN) is a disease characterized by subepithelial immune deposits.In this glomerulopathy inflammatory cells usually are not detected and that in some, or many of the cases, there is not prominent local inflammation, but trapping of immune complexes.

  • Membranous nephropathy

    Disease pathophysiology: 

    Membranous nephropathy (IMN) is an antibody-mediated glomerular disease that is histologically characterized by uniform thickening ofglomerular basement membrane (GBM), caused by subepithelial immune complex deposits. The formation of subepithelial immune deposits and complement activation are responsible for functional impairment of the glomerular capillary wall, causing proteinuria."

     

  • Membranous nephropathy

    Disease statistics: 

    The incidence is about 3 new cases per 100,000 each year in adults. In adults, diabetes mellitus is the most common secondary cause. Minimal change disease accounts for 10%-25% of cases of nephrotic syndrome in adults. The incidence of minimal change disease is higher in children with a reported incidence of 2 per 100,000 per year in Caucasian children and higher rates in Arabian and Asian children.

  • Membranous nephropathy

    Disease treatment:

    Treatment with costly and potentially toxic drugs remains controversial and challenging, partly because of insufficient insight into the pathogenesis of the disease and absence of sensitive biomarkers of disease activity.

  • Membranous nephropathy

    Major research on disease:

    Nephrotic syndrome is a relatively rare but important manifestation of kidney disease. Research On Membranous Glomerulonephritis Global Clinical Trials Review H2. Develop proprietary assays for the identified biomarkers and assess their diagnostic and predictive values in large cohorts.

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  • Hayam I Gad
    Effects of Pravastatin or 12/15 lipoxygenase pathway inhibitors on indices of Diabetic nephropathy in an experimental model of diabetic renal disease
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