Membranous nephropathy (IMN) is an antibody-mediated glomerular disease that is histologically characterized by uniform thickening of (GBM), caused by subepithelial immune complex deposits. The formation of subepithelial immune deposits and complement activation are responsible for functional impairment of the glomerular capillary wall, causing ."
The incidence is about 3 new cases per 100,000 each year in adults. In adults, is the most common secondary cause. Minimal change disease accounts for 10%-25% of cases of in adults. The incidence of minimal change disease is higher in children with a reported incidence of 2 per 100,000 per year in Caucasian children and higher rates in Arabian and Asian children.
Treatment with costly and potentially toxic drugs remains controversial and challenging, partly because of insufficient insight into the pathogenesis of the disease and absence of sensitive biomarkers of disease activity.
Major research on disease:
Nephrotic syndrome is a relatively rare but important manifestation of kidney disease. Research On Membranous Glomerulonephritis Global Clinical Trials Review H2. Develop proprietary assays for the identified biomarkers and assess their diagnostic and predictive values in large cohorts.