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Membranous Nephropathy

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  • Membranous nephropathy


    Membranous nephropathy
     is a major cause of nephrotic syndrome of non-diabetic origin in adults. It is the second or third leading cause of end-stage renal disease in patients with primary glomerulonephritis, and is the leading glomerulopathy that recurs after kidney transplantation (occurring in about 40% of patients).

  • Membranous nephropathy

    Disease pathophysiology

    circulating IgG antibodies directed against endogenous antigens on or near podocyte foot processes form immune complexes C5b-9 (MAC) causes cell signaling silt diaphragm protein disruption redistribution of actin GBM expansion by injured podocytes.

     

  • Membranous nephropathy

    Disease statistics:

    Data from the first 2,935 patients consented to the CKD.QLD registry across five sites was analysed, with a comparison between those with and without Genetic Renal Disease(GRD). QLD registry, national census data and extracted Australian and New Zealand Dialysis and Transplantation (ANZDATA) registry report data respectively

     

  • Membranous nephropathy

    Disease treatment:

    Treatments include: Observation for patients with asymptomatic proteinuria Immunosuppressive therapy for progressive disease or symptomatic nephrotic syndrome - Chlorambucil, cyclosporine, tacrolimus, cyclophosphamide Corticosteroids - not effective when used alone, but used in combination with immunosuppressants Diuretics - may be used in situation of volume overload".

     

  • Membranous nephropathy

    Major research on disease:

    Clinicopathological analysis of idiopathic membranous nephropathy in young adults. Develop proprietary assays for the identified biomarkers and assess their diagnostic and predictive values in large cohorts.

Expert PPTs

Speaker PPTs

  • Hayam I Gad
    Effects of Pravastatin or 12/15 lipoxygenase pathway inhibitors on indices of Diabetic nephropathy in an experimental model of diabetic renal disease
    PPT Version | PDF Version
 

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