Odontogenic infections arise either from pulp death, secondary most commonly from dental decay, alternatively they commence in the pericoronal tissues. In both instances they are of oral microbial origin. Dependent on the type, quantity and virulence of the micro-organisms they may spread into the maxilla or mandible and then into the surrounding face, jaws or neck. Netherlands results in an annual incidence rate primary, histopathologically benign, intraosseous ameloblastoma of approximately 1.5 per million population. There were 341 males and 250 females, the male-female ratio being 1.4: 1. The age at the time of diagnosis was 44.1 years (range 0-98 years) with a peak incidence between the second and sixth decade. The average age in males was 46.3 years compared to an average age in females of 41.3 years.
Often taking a mild course, these infections may also produce life-threatening complications, depending on a patient's immunocompetence and the site of the inflammatory process. These infections are typically polymicrobial, and anaerobic bacteria are thought to play a central etiologic role. Antibiotics are an important component in the treatment of odontogenic infections. The drugs most frequently recommended are penicillin (PEN), amoxicillin-clavulanic acid (AMC), and clindamycin (CLI)—despite reports of substantial resistance to CLI among oral pathogens. Researcxh focusing on the Expression of the transcription factor PITX2 in ameloblastic carcinoma, Primordial odontogenic tumour: clinicopathological analysis of six cases of a previously undescribed entity.